JERUSALEM (AP) 鈥 The Israeli government said a drone was launched toward the prime minister鈥檚 house Saturday, with no casualties, as Iran鈥檚 supreme leader vowed that Hamas would continue its fight against Israel following the killing of the mastermind of last year鈥檚 deadly Oct. 7 attack.

Sirens wailed Saturday morning in Israel, warning of incoming fire from Lebanon, including a drone launched toward Israeli Prime Minister house in Caesarea, the Israeli government said. Neither he nor his wife were home and there were no casualties, said his spokesperson in a statement.

Meanwhile, in Gaza, more than 50 people, including children, have been killed in several Israeli strikes, in less than 24 hours, according to hospital officials and an Associated Press reporter.

In September, Yemen鈥檚 Houthi rebels launched a ballistic missile toward Ben Gurion Airport when Netanyahu鈥檚 plane was landing. The missile was intercepted.

Barrages from Lebanon target northern Israel

In addition to the drone launched at Netanyahu鈥檚 residence, Israel鈥檚 military said some 55 projectiles were fired in two separate barrages at northern Israel from Lebanon on Saturday morning. Four people were injured, one of who had moderate wounds from falling shrapnel, said Israel鈥檚 medical services.

Israel's emergency services said a 50-year-old man was killed after being hit by shrapnel while sitting in his car in northern Israel. In a separate statement, the emergency services said four people were injured from the strikes. It was unclear if the man killed was one of the injured.

Israel's 鈥 a Hamas ally backed by Iran 鈥 has intensified in recent weeks. Hezbollah said Friday that it planned to launch a new phase of fighting by sending more guided missiles and exploding drones into Israel. The militant group鈥檚 longtime leader, Hassan Nasrallah, was in late September, and Israel sent ground troops into Lebanon earlier in October.

Israel also said Saturday it killed Hezbollah鈥檚 deputy commander in the southern town of Bint Jbeil. The army said Nasser Rashid supervised attacks against Israel

In Lebanon, the health ministry said an Israeli airstrike Saturday hit a vehicle on a main highway north of Beirut, killing two people. It was unclear who was in the car when it was struck.

Israeli strikes pound Gaza as Hamas rejects hostage release

A standoff is also ensuing , which it鈥檚 fighting in Gaza, with both signaling resistance to ending the war after the this week. On Friday, Iran鈥檚 supreme leader, Ayatollah Ali Khamenei, said Sinwar鈥檚 death was a painful loss but noted that Hamas carried on despite the killings of other Palestinian militant leaders before him.

鈥淗amas is alive and will stay alive,鈥 Khamenei said.

Since , Friday, Hamas has reiterated its stance that the hostages taken from Israel a year ago will not be released until there is a cease-fire in Gaza and a withdrawal of Israeli troops. The staunch position pushed back against a statement by Netanyahu that his country鈥檚 military will keep fighting until the hostages are released, and will to prevent a severely weakened Hamas from rearming.

Sinwar was the chief architect of the 2023 Hamas raid on Israel that killed some 1,200 people, mostly civilians, and kidnapped another 250. Israel鈥檚 retaliatory has killed over 42,000 Palestinians, according to local health authorities, who do not distinguish combatants from civilians but say more than half the dead are women and children.

More strikes pounded Gaza on Saturday. The Palestinian Health Ministry said in a statement that Israeli strikes hit the upper floors of the Indonesian Hospital in Beit Lahiya, and that forces opened fire at the hospital鈥檚 building and its courtyard, causing panic among patients and medical staff.

At Al-Awda hospital in Jabaliya, in northern Gaza, strikes hit the building鈥檚 top floors, injuring several staff members, the hospital said in a statement. Three houses in Jabaliya were struck overnight Friday, killing at least 30 people, more than half of them women and children, said Fares Abu Hamza, head of the health ministry鈥檚 ambulance and emergency service. At least 80 people were injured.

In central Gaza, at least 10 people were killed, including two children, when a house was hit in the town of Zawayda, according to the al-Aqsa Martyrs Hospital in Deir al-Balah, where the casualties were taken. Another strike killed 11 people, all from the same family, in the Maghazi refugee camp, the same hospital said. Associated Press journalists counted the bodies from both strikes at the hospital.

The strikes knocked out internet networks in northern Gaza, said Paltel, the Palestinian communications company, on Facebook Saturday.

The war , displaced about 90% of its population of 2.3 million people, and left them struggling to find food, water, medicine and fuel.

Opportunity in Sinwar's death

Sinwar鈥檚 killing appeared to be a chance front-line encounter with Israeli troops on Wednesday, and it could shift the dynamics of the war in Gaza even as Israel presses its with ground troops in southern Lebanon and of the country.

Israel has pledged to destroy Hamas politically in Gaza, and killing Sinwar was a top military priority. But Netanyahu said in a speech Thursday announcing the killing that 鈥渙ur war is not yet ended.鈥

Still, the governments of Israel鈥檚 allies and exhausted residents of Gaza expressed hope that Sinwar鈥檚 death would for an end to the fighting.

In Israel, families of hostages still held in Gaza as a way to restart negotiations to bring home their loved ones. There are about 100 hostages remaining in Gaza, at least 30 of whom Israel says are dead.

Associated Press reporters Jack Jeffery from Ramallah, West Bank and Bassem Mroue in Beirut, Lebanon contributed to this report.

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