DUBAI, United Arab Emirates (AP) 鈥 Iran's supreme leader said Friday that negotiations with America 鈥渁re not intelligent, wise or honorable鈥 after President Donald Trump floated nuclear talks with Tehran.

Ayatollah Ali Khamenei also suggested that 鈥渢here should be no negotiations with such a government,鈥 but stopped short of issuing a direct order not to engage with Washington.

Khamenei's remarks upend months of signals from Tehran to the United States that it wanted to negotiate over in exchange for the lifting of crushing economic sanctions worth billions of dollars.

What happens next remains unclear, particularly as reformist President Masoud Pezeshkian campaigned on and promised as recently as Thursday entering into a dialogue with the West.

Khamenei鈥檚 remarks to air force officers in Tehran appeared . However, the 85-year-old Khamenei has always been careful with remarks about negotiating with the West. That includes balancing the demands of reformists within the country who want the talks against hard-line elements within Iran鈥檚 theocracy, including the paramilitary Revolutionary Guard.

Khamenei noted that Trump unilaterally withdrew from the earlier nuclear deal under which Iran drastically limited its enrichment of uranium and overall stockpile of the material, in exchange for crushing sanctions being removed.

鈥淭he Americans did not uphold their end of the deal,鈥 Khamenei said. 鈥淭he very person who is in office today tore up the agreement. He said he would, and he did.鈥

He added: "This is an experience we must learn from. We negotiated, we gave concessions, we compromised鈥 but we did not achieve the results we aimed for. And despite all its flaws, the other side ultimately violated and destroyed the agreement.鈥

It's not clear what sparked Khamenei's remarks. However, they come after Trump suggested he wanted to deal with Tehran, even while his 鈥渕aximum pressure" approach to Iran on Tuesday.

鈥淚鈥檓 going to sign it, but hopefully we鈥檙e not going to have to use it very much,鈥 he said from the Oval Office. 鈥淲e will see whether or not we can arrange or work out a deal with Iran.鈥

鈥淲e don鈥檛 want to be tough on Iran. We don鈥檛 want to be tough on anybody,鈥 Trump added. 鈥淏ut they just can鈥檛 have a nuclear bomb.鈥

Trump followed with another online message on Wednesday, saying: 鈥淩eports that the United States, working in conjunction with Israel, is going to blow Iran into smithereens, ARE GREATLY EXAGGERATED.鈥

鈥淚 would much prefer a Verified Nuclear Peace Agreement, which will let Iran peacefully grow and prosper,鈥 he wrote on Truth Social. 鈥淲e should start working on it immediately, and have a big Middle East Celebration when it is signed and completed.鈥

Trump did not elaborate.

Khamenei, like other Iranian leaders, uses elliptical comments to indirectly govern policy while not boxing himself into any one decision. As supreme leader, he's also created a vast bureaucracy that competes with itself for influence, including with its civilian leadership under Pezeshkian.

As recently as Thursday, Pezeshkian suggested Iran could open itself up to even more inspections from the United Nations' nuclear watchdog, the International Atomic Energy Agency.

鈥淭hey (can) come and inspect one hundred times more since we are not supposed to go after鈥 a nuclear weapon, Pezeshkian told foreign diplomats.

Iranian diplomats for years have pointed to Khamenei鈥檚 preachings as a binding fatwa, or religious edict, that Iran won't build an atomic bomb.

Iran long has insisted its nuclear program is for peaceful purposes. However, it now enriches uranium to 60% purity 鈥 a short, technical step from weapons-grade levels of 90%. Iranian officials increasingly suggest Tehran could pursue an atomic bomb. U.S. intelligence agencies assess that Iran has yet to begin a weapons program, but has 鈥渦ndertaken activities that better position it to produce a nuclear device, if it chooses to do so.鈥

Earlier in the week, Trump also said that displaced Palestinians in Gaza could be permanently resettled outside the war-torn territory and proposed the U.S. take 鈥渙wnership鈥 in redeveloping the area into 鈥渢he Riviera of the Middle East.鈥

While not directly linking Trump's comments on Gaza, Khamenei appeared to be referencing them in his remarks as well.

鈥淭he Americans sit, redrawing the map of the world 鈥 but only on paper, as it has no basis in reality," Khamenei said. 鈥淭hey make statements about us, express opinions and issue threats. If they threaten us, we will threaten them in return. If they act on their threats, we will act on ours. If they violate the security of our nation, we will, without a doubt, respond in kind.鈥

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Associated Press writers Amir Vahdat and Nasser Karimi in Tehran, Iran, contributed to this report.

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